Launched in 1998, the restaurant offers a creative and personal take on the cuisine of the chef-owner’s native Gascony in south-west France.
The restaurant has held a Michelin star for nearly 25 years, having first been awarded one in 2002.
No reason has been given for the decision, with Aussignac saying he is calling time on the restaurant “with both gratitude and a heavy heart”.
In a post on Instagram, he added: “It has been our privilege to celebrate the cuisine and spirit of Gascony in London; welcoming guests from around the world and sharing a dining experience rooted in tradition, seasonality and creativity.
“We are deeply thankful to our loyal guests, and to our incredible team past and present, whose passion and dedication brought Club Gascon to life every day. We’re also incredibly grateful for the loyalty, support and enthusiasm shown by our community, and for the recognition we have received. Thank you for being part of our story.”
Club Gascon’s final dinner service will take place on 28 March.