Led by executive chef Glen Ballis, the food will take inspiration from the wider Mediterranean, focusing on ingredient-led cooking.
The restrained menu will include grilled fish, carefully sourced meats and seasonal vegetables.
Accompanying the food offering will be a curated wine list emphasizing quality and craftsmanship.
Located in the former Wulf & Lamb site at the intersection of Paddington and Chiltern Street, the space will include stone bar, earthy tones, and integrated greenery.
Clio will join other Greek dining destinations in Marylebone including Fotia, The Real Greek and Opso.