The restaurant, which opened in 2024, is listed on Google as permanently closed and is understood to have ceased trading in the past couple of months.
It follows the shuttering of the group’s outposts in Nottingham and Derby, which are both believed to have closed in the last year.
Restaurant’s sister title MCA has reached out to Little Caesars for comment.
The London closure leaves Little Caesars without a presence in the UK, just over two years after the US pizza chain described the country as “a key market for global expansion”.
The Detroit-based brand, which launched in 1959 as a single, family-owned restaurant, opened its first site following its return to the UK in Chellaston, Derby, in late 2022.
It followed this with locations in Nottingham and London.
Carlos Vidal, vice-president of international development at Little Caesars, told MCA the chain had its sights set on “bigger city locations” following its launch in the capital.
“We are looking to set our sights on bigger city locations, where we can be present within an exciting and dynamic QSR scene,” Vidal said.
He added that Little Caesars had opportunities available for new franchisees and was seeking multi-site operators to support its UK growth.
Vidal went on to describe the UK QSR market as “thriving” and a key consideration in the company’s decision to re-enter the country in 2022.
“Our first Little Caesars site opening was in Derby and has been well received, and we’ve noticed a steady flow of sales since opening in 2022,” he added.
Little Caesars previously made a play for the UK market in the mid-1980s and, at its peak, operated about 18 sites across the country. However, it wound down its UK operation in 2000 after failing to gain a substantial foothold.